TABLE 1.

IC₅₀, FICI₅₀, and ΣFICI₅₀ of the combination of itraconazole and ezetimibe against L. infantum intracellular amastigotes^a

ITR/EZ ratio	Mean IC50 (μM) (SD)		FICI
	ITR	EZ	ITR	EZ	ΣFICI	${}_{\overline{x}}\Sigma \text{FICI}$
5:0	0.89 (0.73–1.08)
4:1	0.53 (0.45–0.63)	1.34 (1.12–1.59)	0.59	0.11	0.7
3:2	0.30 (0.13–0.69)	0.80 (0.71–0.89)	0.33	0.06	0.39
2:3	0.28 (0.16–0.48)	4.19 (2.4–7.33)	0.31	0.36	0.67	0.56
1:4	0.15 (0.10–0.22)	3.63 (3.10–4.25)	0.16	0.31	0.47
0:5		11.46 (10.11–12.98)

^aIC₅₀, concentration that inhibits 50% of parasite growth (followed by the standard deviation [SD]); ITR, itraconazole; EZ, ezetimibe. According to published guidelines, a fractional inhibitory concentration index (FICI) of 0.5 to 4.0 is indicative of an additive effect.