TABLE 3.
Group (treatment) | No. of animals/group | Dose (mg/kg)/time of treatment initiation postchallenge (h)a | Mean LD50 ± SD |
---|---|---|---|
1 (vehicle) | 12 | NA/24 | 233 ± 38.0 |
2 (ciprofloxacin) | 12 | 30/12 | 278 ± 13.7 |
3 (ciprofloxacin) | 12 | 30/24 | 199 ± 0.2 |
4 (tebipenem HBr) | 12 | 33.3/12 | 239 ± 55.1 |
5 (tebipenem HBr) | 12 | 33.3/24 | 244 ± 22.4 |
NA, not applicable.