TABLE 2.
PPQ susceptibilities categorized based on IC50, IC90, and the presence of bimodal curves and AUCa
| Parasite group or P value | Median (IQR) |
PSA ≥ 10%, no. (%) | Median PSA (IQR) | ||
|---|---|---|---|---|---|
| AUC | IC50 (nM) | IC90 (nM) | |||
| Groups | |||||
| 1 (red) | 0.0 (0.0–5.7) | 3.9 (3.2–4.9) | 6.6 (5.4–7.6) | 3 (6.3) | 3.6 (1.8–6.2) |
| 2 (green) | 5.8 (0.0–11.1) | 6.3 (5.5–6.8) | 11.6 (10.1–13.8) | 4 (8.7) | 4.3 (2.2–6.1) |
| 3 (blue) | 22.1 (17.2–33.0) | 7.7 (7.2–8.6) | 12.3 (10.6–16.6) | 0 (0.0) | 3.9 (1.6–6.0) |
| P valuesb | |||||
| * | P < 0.0001 | P < 0.0001 | P < 0.0001 | ND | P = 0.6450 |
| ** |
P = 0.0034 (1 vs 3) P < 0.0001 (2 vs 3) P = 0.4108 (1 versus 2) |
P < 0.0001 (1 vs 2, 1 vs 3, 2 vs 3) |
P < 0.0001 (1 vs 2, 1 vs 3) P = 0.1230 (2 versus 3) |
ND | ND |
a
AUC, area under curve; IQR, interquartile range; PSA, piperaquine survival assay score; ND, not done.
b
*, Comparison among three groups (Kruskal-Wallis test); **, comparison between two groups (Mann-Whitney U test).