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Gene duplication and amplification (GDA) in clinical Burkholderia pseudomallei strain DR50054E. The 22-kb amplified regions in chromosome 2 of relapse strain DR50054E involve 20 genes from BPSS0944, BPS_RS23855 to BPSS0960, and BPS_RS23950 (red line) (see Table S3 in the supplemental material), including penA (purple line). The average sequence read coverage of this GDA region is approximately 6-fold higher than the average genome coverage.
