TABLE 5.

Whole-genome analysis of antibiotic resistance-associated genes in B. pseudomallei isolates^a

^aMutations were amino acid changes due to single nucleotide polymorphism, deletion, and frameshift mutation observed in B. pseudomallei isolates with decreased antibiotic susceptibility compared to K96243A. A, primary isolate; E, relapse isolate; MLST, multilocus sequence type; WT, wild type; fs, frameshift mutation; del, deletion; S, susceptible. Boldface in antibiotic susceptibility indicates resistance (R), less susceptible (LS), or intermediate (I). The mutations colored in blue were also found in antibiotic-susceptible B. pseudomallei isolates. Those colored in green were known CAZ-R variants (20, 22). Novel mutations found in this study are colored in red.