TABLE 2.
Alterations associated with colistin and NOSO-502 resistance in K. pneumoniae NCTC13442 mutants
| K. pneumoniae strain | Mutant | Amino acid alteration |
||||||
|---|---|---|---|---|---|---|---|---|
| CrrA | CrrB | MgrB | PhoP | PhoQ | PmrA | PmrB | ||
| NCTC13442 (wt) | NA | 1-nt dela | ||||||
| NCTC13442 | NC_P151L | P151L | 1-nt dela | |||||
| NCTC13442 | NC_W140R | W140R | 1-nt dela | |||||
| NCTC13442 | NC_P151T | P151T | 1-nt dela | |||||
| NCTC13442 | NC_P151A | P151A | 1-nt dela | |||||
| NCTC13442 | NC_F33Y | F33Y | 1-nt dela | |||||
| NCTC13442 | NC_S8N | S8N | 1-nt dela | |||||
| NCTC13442 | NC_Y34N | Y34N | 1-nt dela | |||||
a
Similar single 1-nt deletion (gene position 66) of phoQ inducing a frameshift in the first 5% of the protein sequence and therefore most probably a complete functional impairment.