Table 1.
Preclinical studies of spinal fusion using stem cells.
|
Study |
Animals |
Conditions |
Fusion, % |
| Fu et al16 | 24 rabbits | Autograft | 92 |
| Alginate + MSC + BMP2 | 92 | ||
| Alginate + MSC | 67 | ||
| Alginate + BMP2 | 0 | ||
| Bae et al54 | 53 rats | rhBMP2/ACS + fresh syngeneic BMA transplant | 89 |
| rhBMP2/2ACS only | 50 | ||
| rhBMP2/1ACS only | 33 | ||
| ACS + fresh syngeneic BMA transplant | 0 | ||
| ACS only | 0 | ||
| Gupta et al47 | 24 sheep | TCP + bone marrow cells | 33 |
| TCP + whole marrow | 8 | ||
| TCP | 0 | ||
| Autograft | 25 | ||
| Minamide et al48 | 30 rabbits | MSC-BMP-FGF | 86 |
| MSC-FGF | 43 | ||
| MSC-BMP | 28 | ||
| MSC | 0 | ||
| Autograft | 57 | ||
| Cinotti et al49 | 40 rabbits | Ceramic + MSC | 85 |
| Ceramic + bone marrow | 50 | ||
| Ceramic | 30 | ||
| Autograft | 25 | ||
| Kai et al50 | 30 rabbits | Ceramic + cells | 100 |
| Ceramic + cells + BMP | 100 | ||
| Ceramic | 50 | ||
| Autograft | 67 | ||
| Valdes et al56 | 53 rabbits | 60M rhBMP6 stimulated OPC | 62 |
| 30M rhBMP6 stimulated OPC | 54 | ||
| Autograft | 55 | ||
| DBM | 40 | ||
| Decortication alone | 0 | ||
| Minamide et al45 | 36 rabbits | BMP-HA | 100 |
| High marrow cells | 71 | ||
| Low marrow cells | 0 | ||
| Autograft | 57 | ||
| Nakajima et al51 | 24 rabbits | Osteogenic MSC | 80 |
| MSC | 33 | ||
| Hydroxyapatite | 0 | ||
| Autograft | 67 | ||
| Wang et al52 | 9 monkeys | MSC+ ceramic | 67 |
| Ceramic | 17 | ||
| Autograft | 83 | ||
| Cui et al57 | 52 rats | Bone marrow | 50 |
| DI-BAG cells | 100 | ||
| Matrix only | 0 | ||
| Cuenca-López et al53 | 34 sheep | HA + MSC | 35 |
| HA | 22 | ||
| Allograft | 70 | ||
| Autograft | 70 | ||
| Miyazaki et al55 | 48 rats | Collagen + adipose-derived MSC + adeno-BMP2 | 100 |
| Collagen + marrow-derived MSC + adeno-BMP2 | 100 | ||
| Collagen + BMP2 | 100 | ||
| Collagen + adipose-derived MSC + adeno-LacZ | 0 | ||
| Collagen + marrow-derived MSC + adeno-LacZ | 0 | ||
| Collagen alone | 0 |
Abbreviations: ACS, absorbable collagen sponges; Adeno-LacZ, study specific; BMA, bone marrow aspirate; BMP2, bone morphogenic protein; DBM, demineralized bone matrix; DI-BAG, study specific; FGF, fibroblast growth factor; HA, hydroxyapatite; MSC, mesenchymal stem cell; OPC, osteoprogenitor cells; TCP, tricalcium phosphate.