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Prognostic effects of TP53 mutation (Mut-TP53) and p53 overexpression (p53high) in patients with MYC rearrangement (MYC-R). A, Patients with DLBCL with concurrent MYC-R and p53high displayed poor OS and PFS but showed little additive negative effect to that of single MYC-R or p53high abnormality. B, Concurrent Mut-TP53 and MYC-R synergistically worsened the OS and PFS in DLBCL. C and D, TP53 mutation had significantly adverse impact independent of MYC-R status.
