Table 2.
List of differentially expressed genes related to the initiation of axonal self‐destruction in TME.
| Gene symbol | Gene title | Probe set ID† | Time post infection | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 14 | 42 | 98 | 196 | |||||||
| Fold change‡ | P‐value§ | Fold change‡ | P‐value§ | Fold change‡ | P‐value§ | Fold change‡ | P‐value§ | |||
| APP | Amyloid beta (A4) precursor protein | 1420621_a_at | 1.03 | 0.9372 | −1.06 | 0.9372 | −1.07 | 0.1255 | −1.05* | 0.0152 |
| APP | Amyloid beta (A4) precursor protein | 1427442_a_at | 1.06* | 0.0260 | −1.01* | 0.0260 | −1.03 | 0.3290 | −1.04* | 0.0260 |
| APP | Amyloid beta (A4) precursor protein | 1444705_at | 1.51* | 0.0411 | 1.04* | 0.0411 | 1.06 | 0.5368 | −1.03 | 0.6991 |
| Atg5 | Autophagy‐related 5 (yeast) | 1415684_at | −1.13 | 0.1797 | −1.11 | 0.0649 | −1.14* | 0.0087 | −1.13* | 0.0411 |
| Bdnf | Brain‐derived neurotrophic factor | 1422168_a_at | −1.19* | 0.0411 | −1.23* | 0.0411 | −1.40* | 0.0173 | −1.14 | 0.2403 |
| Casp6 | Caspase 6 | 1415995_at | 1.14* | 0.0411 | 1.15* | 0.0411 | 1.41* | 0.0303 | 1.30* | 0.0022 |
| Cd200r1 | CD200 receptor 1 | 1422191_at | 1.03 | 0.9372 | 1.27* | 0.0043 | 1.29* | 0.0087 | 1.20* | 0.0411 |
| Cd200r3 | CD200 receptor 3 | 1453813_at | 1.09 | 0.2403 | 1.26* | 0.0152 | −1.05 | 0.3290 | 1.08 | 0.3095 |
| Cd200r4 | Cd200 receptor 4 | 1435313_at | −1.01 | 0.8182 | 2.36* | 0.0022 | 4.79* | 0.0043 | 4.21* | 0.0022 |
| Gpr109a | G protein‐coupled receptor 109A | 1419721_at | 1.67* | 0.0022 | 4.00* | 0.0022 | 5.27* | 0.0043 | 3.27* | 0.0022 |
| Map3k12 | Mitogen‐activated protein kinase kinase kinase 12 | 1417115_at | −1.02 | 0.3939 | −1.06* | 0.0022 | −1.11* | 0.0173 | −1.12* | 0.0022 |
| Mapk8 | Mitogen‐activated protein kinase 8 | 1420932_at | −1.03 | 0.9372 | −1.10* | 0.0022 | −1.10* | 0.0087 | −1.03 | 0.8182 |
| Mapk8 | Mitogen‐activated protein kinase 8 | 1437045_at | 1.72* | 0.0043 | 1.11 | 0.6991 | −1.10 | 0.7922 | −1.04 | 0.8182 |
| Mapk8 | Mitogen‐activated protein kinase 8 | 1457936_at | 1.01 | 1.0000 | −1.24* | 0.0411 | −1.18 | 0.3290 | −1.12 | 0.3939 |
| Nmnat1 | Nicotinamide nucleotide adenylyltransferase 1 | 1425773_s_at | −1.06 | 0.9372 | 1.00 | 0.6991 | −1.06 | 0.4286 | −1.44* | 0.0022 |
| Nmnat2 | Nicotinamide nucleotide adenylyltransferase 2 | 1436155_at | −1.02 | 0.2403 | −1.09* | 0.0043 | −1.08* | 0.0173 | −1.08* | 0.0411 |
| Parp1 | Poly (ADP‐ribose) polymerase family, member 1 | 1422502_at | 1.01 | 0.8182 | −1.03 | 0.3939 | 1.09 | 0.1255 | 1.16* | 0.0152 |
| Pttg1 | Pituitary tumor‐transforming 1 | 1438390_s_at | −1.05 | 0.6991 | 1.20* | 0.0152 | 1.36* | 0.0087 | 1.07 | 0.2403 |
| Ret | Ret proto‐oncogene | 1421359_at | −1.19 | 0.1797 | −1.22 | 0.1797 | −1.12* | 0.0303 | 1.10 | 0.0931 |
| Ube4b | Ubiquitination factor E4B, UFD2 homolog (Saccharomyces cerevisiae) | 1432499_a_at | −1.01 | 0.9372 | −1.12* | 0.0260 | −1.12 | 0.1255 | −1.06 | 0.3939 |
| Vcp /// LOC675857 | Valosin containing protein /// similar to Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)‐ATPase p97 subunit) (valosin‐containing protein) (VCP) | 1423030_at | 1.02 | 0.4848 | 1.02 | 0.4848 | 1.02 | 0.7922 | 1.09* | 0.0260 |
*
Statistically significant difference (P ≤ 0.05).
†
The probe set ID represents the unique probe set identifier of the Affymetrix mouse genome 430 2.0 array.
‡
The fold change was calculated as the ratio of the inverse‐transformed arithmetic means of the log2‐transformed expression values of Theiler's murine encephalomyelitis virus (TMEV)‐infected vs. mock‐infected mice. Downregulations are shown as negative reciprocal values.
§
P‐value as obtained by pairwise comparison of TMEV‐infected and mock‐infected mice by Mann–Whitney U‐test.