Table 3.
List of axonal transport‐related differentially expressed genes.
| Gene symbol | Gene title | Probe set ID† | Time post infection | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 14 | 42 | 98 | 196 | |||||||
| Fold change‡ | P‐value§ | Fold change‡ | P‐value§ | Fold change‡ | P‐value§ | Fold change‡ | P‐value§ | |||
| APP | Amyloid beta (A4) precursor protein | 1427442_a_at | 1.06* | 0.0260 | −1.01 | 0.5887 | −1.03 | 0.3290 | −1.04* | 0.0260 |
| Dnahc2 /// Dnhd3 | Dynein, axonemal, heavy chain 2 /// dynein heavy chain domain 3 | 1438763_at | −1.18* | 0.0087 | −1.17 | 0.0931 | −1.23* | 0.0043 | −1.10 | 0.3939 |
| Dnahc5 | Dynein, axonemal, heavy chain 5 | 1421434_at | −1.00 | 0.8182 | 1.08 | 0.5887 | 1.02 | 0.9307 | −1.16* | 0.0260 |
| Dnahc8 | Dynein, axonemal, heavy chain 8 | 1425692_a_at | −1.06 | 0.3939 | 1.01 | 0.8182 | −1.16* | 0.0303 | 1.01 | 0.9372 |
| Dnahc9 | Dynein, axonemal, heavy chain 9 | 1457401_at | −1.03 | 0.6991 | −1.06 | 0.4848 | −1.02 | 0.7922 | −1.14* | 0.0260 |
| Dnaic1 | Dynein, axonemal, intermediate chain 1 | 1437094_x_at | −1.13 | 0.0649 | −1.10 | 0.2403 | −1.24* | 0.0087 | −1.13 | 0.0931 |
| Dnalc1 | Dynein, axonemal, light chain 1 | 1455630_at | −1.02 | 0.5887 | −1.13* | 0.0022 | −1.15* | 0.0087 | −1.11 | 0.0931 |
| Dnalc4 | Dynein, axonemal, light chain 4 | 1416870_at | 1.00 | 1.0000 | −1.13* | 0.0152 | −1.03 | 0.7922 | −1.02 | 0.9372 |
| Dnali1 | Dynein, axonemal, light intermediate polypeptide 1 | 1455379_at | 1.14 | 0.3939 | −1.01 | 1.0000 | −1.08 | 0.5368 | 1.17* | 0.0260 |
| Dync1i1 | Dynein cytoplasmic 1 intermediate chain 1 | 1416361_a_at | −1.10* | 0.0022 | −1.08* | 0.0152 | −1.16* | 0.0043 | −1.23* | 0.0043 |
| Dync1li1 | Dynein cytoplasmic 1 light intermediate chain 1 | 1424947_at | −1.11* | 0.0411 | −1.09 | 0.0649 | −1.20* | 0.0303 | −1.15 | 0.0931 |
| Dync2h1 | Dynein cytoplasmic 2 heavy chain 1 | 1429250_at | 1.10 | 0.2403 | −1.15* | 0.0260 | −1.12 | 0.0823 | −1.08 | 0.1320 |
| Dynll1 | Dynein light chain LC8‐type 1 | 1448682_at | −1.02 | 0.4848 | −1.09* | 0.0411 | −1.08 | 0.2468 | −1.00 | 0.5887 |
| Dynll1 /// EG627788 /// LOC637840 /// LOC672375 | Dynein light chain LC8‐type 1 /// predicted gene, EG627788 /// Similar to dynein, cytoplasmic, light peptide /// similar to dynein, cytoplasmic, light peptide | 1417339_a_at | −1.12 | 0.0649 | −1.14* | 0.0087 | −1.04 | 0.4286 | −1.10* | 0.0411 |
| Dynll2 | Dynein light chain LC8‐type 2 | 1418258_s_at | 1.03 | 0.9372 | −1.00 | 0.9372 | −1.10* | 0.0173 | −1.15* | 0.0411 |
| Dynlrb1 | Dynein light chain roadblock‐type 1 | 1428257_s_at | −1.09 | 0.0649 | −1.11* | 0.0022 | −1.06 | 0.0823 | −1.10* | 0.0022 |
| Dynlt1 | Dynein light chain Tctex‐type 1 | 1428116_a_at | 1.07 | 0.3095 | 1.11 | 0.2403 | 1.25* | 0.0303 | 1.22* | 0.0411 |
| Dynlt1 /// LOC671261 | Dynein light chain Tctex‐type 1 /// similar to Cytoplasmic dynein light chain (T‐complex testis‐specific protein 1) (TCTEX‐1) | 1453473_a_at | 1.08 | 0.3095 | 1.06 | 0.9372 | 1.28* | 0.0087 | 1.19 | 0.0649 |
| Dynlt3 | Dynein light chain Tctex‐type 3 | 1459854_s_at | −1.13* | 0.0022 | −1.09 | 0.1797 | −1.02 | 0.6623 | −1.10 | 0.0649 |
| Kif12 | Kinesin family member 12 | 1424910_at | −1.01 | 0.4848 | 1.06 | 0.2403 | −1.13* | 0.0303 | −1.01 | 0.9372 |
| Kif17 | Kinesin family member 17 | 1419827_s_at | 1.06 | 0.6991 | −1.07* | 0.0152 | −1.08 | 0.1255 | −1.15 | 0.0649 |
| Kif18a | Kinesin family member 18A | 1424107_at | −1.07 | 0.3095 | −1.03 | 0.5887 | 1.17* | 0.0087 | −1.05 | 0.3939 |
| Kif21a | Kinesin family member 21A | 1450738_at | 1.04 | 0.8182 | −1.04 | 0.9372 | −1.33* | 0.0043 | −1.22 | 0.1797 |
| Kif21b | Kinesin family member 21B | 1435772_at | 1.21* | 0.0260 | 1.10 | 0.1320 | 1.12 | 0.1255 | −1.04 | 0.4848 |
| Kif23 | Kinesin family member 23 | 1455990_at | −1.16 | 0.1320 | 1.21* | 0.0260 | 1.28* | 0.0303 | 1.02 | 0.6991 |
| Kif24 | Kinesin family member 24 | 1431937_at | −1.05 | 0.8182 | −1.14 | 0.0931 | −1.04 | 0.6623 | −1.22* | 0.0260 |
| Kif2a | Kinesin family member 2A | 1454107_a_at | 1.20 | 0.8182 | 1.19 | 0.1320 | −1.16 | 0.3290 | −1.47* | 0.0260 |
| Kif2c | Kinesin family member 2C | 1432392_at | −1.13 | 0.0931 | 1.04 | 0.8182 | 1.04 | 0.7922 | −1.24* | 0.0260 |
| Kif3b | Kinesin family member 3B | 1450074_at | −1.09 | 0.1320 | 1.05 | 0.3095 | −1.22* | 0.0173 | −1.12 | 0.3939 |
| Kif3c | Kinesin family member 3C | 1448946_at | 1.06 | 0.0649 | −1.05 | 0.1320 | −1.07* | 0.0087 | −1.10* | 0.0022 |
| Kif5a | Kinesin family member 5A | 1434670_at | 1.02 | 1.0000 | −1.10* | 0.0022 | −1.19* | 0.0043 | −1.18* | 0.0022 |
| Kif5a /// Kif5c | Kinesin family member 5A /// kinesin family member 5C | 1450249_s_at | −1.16 | 0.2403 | −1.04 | 0.3095 | −1.38* | 0.0043 | −1.33* | 0.0087 |
| Kif5b | Kinesin family member 5B | 1418431_at | 1.03 | 1.0000 | −1.09 | 0.2403 | −1.54* | 0.0303 | −1.31 | 0.0931 |
| Kif5c | Kinesin family member 5C | 1422945_a_at | −1.03 | 0.6991 | −1.04 | 0.6991 | −1.52 | 0.0519 | −1.48* | 0.0087 |
| Kifap3 | Kinesin‐associated protein 3 | 1451783_a_at | −1.04 | 0.1797 | −1.08* | 0.0260 | −1.14* | 0.0087 | −1.09* | 0.0043 |
| Klc2 | Kinesin light chain 2 | 1418214_at | −1.04 | 0.8182 | −1.09 | 0.0649 | −1.17* | 0.0043 | −1.16* | 0.0022 |
| Kns2 | Kinesin 2 | 1417005_at | −1.04 | 0.0931 | −1.03 | 0.1320 | −1.12* | 0.0087 | −1.09 | 0.0649 |
| Mapt | Microtubule‐associated protein tau | 1424719_a_at | 1.05 | 0.3095 | −1.07 | 0.1797 | −1.16* | 0.0043 | −1.06 | 0.5887 |
| Nefh | Neurofilament, heavy polypeptide | 1424847_at | −1.01 | 0.8182 | −1.07* | 0.0260 | −1.12* | 0.0303 | −1.10 | 0.0649 |
| Nefl | Neurofilament, light polypeptide | 1426255_at | −1.03 | 0.0649 | −1.02 | 0.5887 | −1.10* | 0.0173 | −1.08 | 0.0931 |
| Ppp2ca | Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 1417367_at | −1.03 | 0.1320 | −1.07* | 0.0022 | −1.07* | 0.0303 | −1.03* | 0.0043 |
| Ppp2cb | Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform | 1421823_a_at | −1.03 | 0.6991 | −1.12* | 0.0043 | −1.16 | 0.1255 | −1.11* | 0.0087 |
| Ppp2r1a | Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform | 1438383_x_at | 1.02 | 0.5887 | 1.02 | 0.9372 | −1.06* | 0.0087 | −1.06* | 0.0152 |
| Ppp2r2a | Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform | 1429715_at | 1.04 | 0.4848 | −1.07 | 0.0649 | −1.21* | 0.0087 | −1.08 | 0.1320 |
| Ppp2r2b | Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform | 1426621_a_at | −1.09 | 0.1320 | −1.05 | 0.1320 | −1.20 | 0.0519 | −1.14* | 0.0260 |
| Ppp2r2c | Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform | 1438671_at | 1.05 | 0.3095 | −1.12* | 0.0260 | −1.20* | 0.0043 | −1.23* | 0.0043 |
| Ppp2r3a | Protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha | 1455198_a_at | −1.09 | 0.1320 | −1.15* | 0.0260 | −1.12 | 0.0823 | −1.05 | 0.5887 |
| Ppp2r5e | Protein phosphatase 2, regulatory subunit B (B56), epsilon isoform | 1428462_at | −1.01 | 1.0000 | −1.13* | 0.0087 | −1.15* | 0.0043 | −1.16* | 0.0043 |
| Prnp | Prion protein | 1446507_at | 1.07 | 0.4848 | 1.08 | 0.8182 | −1.02 | 1.0000 | −1.12* | 0.0152 |
| Spata6 | Spermatogenesis associated 6 | 1418650_at | −1.07 | 0.6991 | 1.02 | 0.9372 | 1.11 | 0.1255 | 1.16* | 0.0260 |
| Tuba1 | Tubulin, alpha 1 | 1418884_x_at | −1.05* | 0.0260 | −1.03 | 0.1797 | −1.02 | 0.2468 | −1.11* | 0.0022 |
| Tuba2 | Tubulin, alpha 2 | 1423846_x_at | −1.01 | 0.8182 | −1.00 | 0.9372 | −1.04* | 0.0173 | −1.04* | 0.0260 |
| Tuba3 | Tubulin, alpha 3 | 1448296_x_at | −1.10 | 0.0931 | −1.13* | 0.0152 | −1.09* | 0.0043 | −1.14* | 0.0087 |
| Tuba3 /// Tuba7 /// LOC384954 | Tubulin, alpha 3 /// tubulin, alpha 7 /// similar to tubulin, alpha 1 | 1416311_s_at | −1.14 | 0.2403 | −1.16* | 0.0411 | −1.09* | 0.0303 | −1.17* | 0.0411 |
| Tuba4 | Tubulin, alpha 4 | 1417373_a_at | −1.01 | 0.2403 | −1.05* | 0.0022 | −1.13* | 0.0043 | −1.13* | 0.0152 |
| Tuba6 /// EG626534 | Tubulin, alpha 6 /// predicted gene, EG626534 | 1448232_x_at | 1.11 | 0.3939 | 1.76* | 0.0022 | 2.12* | 0.0043 | 1.53* | 0.0022 |
| Tuba8 | Tubulin, alpha 8 | 1419518_at | 1.03 | 0.8182 | −1.01 | 0.9372 | −1.15* | 0.0303 | −1.10 | 0.3939 |
| Tubb2a | Tubulin, beta 2a | 1427838_at | −1.02 | 0.9372 | −1.04 | 0.9372 | −1.04 | 0.7922 | −1.12* | 0.0411 |
| Tubb2a /// Tubb2b /// LOC665524 /// LOC671656 | Tubulin, beta 2a /// tubulin, beta 2b /// similar to tubulin, beta 3 /// similar to tubulin, beta 3 | 1427347_s_at | −1.07 | 0.0649 | −1.05 | 0.0649 | −1.05 | 0.0519 | −1.10* | 0.0022 |
| Tubb2b | Tubulin, beta 2b | 1452679_at | −1.10 | 0.1320 | −1.03 | 0.3939 | 1.11 | 0.2468 | −1.22* | 0.0411 |
| Tubb2c | Tubulin, beta 2c | 1456470_x_at | −1.07 | 0.5887 | −1.00 | 1.0000 | −1.02 | 0.5368 | −1.20* | 0.0152 |
| Tubb3 | Tubulin, beta 3 | 1415978_at | −1.08 | 0.2403 | −1.09 | 0.1797 | −1.16* | 0.0043 | −1.00 | 0.8182 |
| Tubb4 | Tubulin, beta 4 | 1423221_at | 1.05 | 0.6991 | −1.00 | 0.9372 | −1.13 | 0.0823 | −1.24* | 0.0022 |
| Tubb5 | Tubulin, beta 5 | 1455719_at | 1.06 | 0.3939 | 1.28* | 0.0022 | 1.49* | 0.0043 | 1.33* | 0.0022 |
| Tubb6 | Tubulin, beta 6 | 1416431_at | −1.03 | 0.9372 | 1.26* | 0.0152 | 1.39* | 0.0303 | 1.39* | 0.0087 |
| Uchl1 | Ubiquitin carboxy‐terminal hydrolase L1 | 1448260_at | −1.11 | 0.2403 | −1.09* | 0.0152 | −1.24* | 0.0043 | −1.14* | 0.0411 |
*
Statistically significant difference (P ≤ 0.05).
†
The probe set ID represents the unique probe set identifier of the Affymetrix mouse genome 430 2.0 array.
‡
The fold change was calculated as the ratio of the inverse‐transformed arithmetic means of the log2‐transformed expression values of Theiler's murine encephalomyelitis virus (TMEV)‐infected vs. mock‐infected mice. Downregulations are shown as negative reciprocal values.
§
P‐value as obtained by pairwise comparison of TMEV‐infected and mock‐infected mice by Mann–Whitney U‐test.