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. 2021 Apr 21;17(4):e1009064. doi: 10.1371/journal.ppat.1009064

Fig 6. Similar virus-neutralizing titers in vaccinated mice and COVID-19 patients.

Fig 6

VSVΔG(S) neutralization activity of sera from vaccinated mice and human immune sera tested positive for S antibodies by ELISA were compared. The graph shows percentage of GFP-positive cells in relation to medium controls and in dependence of dilution. All ELISA-positive human sera revealed VSV(S)-neutralizing activity (see S2 Fig) and are included in the grey boxes showing activity at the indicated dilutions. Primed mice (d28) exhibited neutralizing activity comparable to those of human patients, while boosted mice (d35 and d56) exhibited superior activity. Bottom and top of each box represent the first and third quartiles respectively. Whiskers represent the lowest and highest data points of the lower and upper quartile respectively. Student’s t-test and One-way ANOVA were performed to determine statistical significance.