Fig. 4.

(A) Electrostatic potential surface representation of the spike monomer, calculated using the DelPhi web-server [77], [78]. The left hand side presents the face containing the PRRARS furin cleavage site and 245H-S247R site, while the right hand side is the opposite face. Representative snapshots obtained from MD frames at 100 ns of the (B) HS and the (C) HP dodecasaccharides bound to the S protein in the up conformation. The spheres represent glycosylations and the GAG oligosaccharides as green spheres. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)