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. Author manuscript; available in PMC: 2021 Nov 18.
Published in final edited form as: J Am Chem Soc. 2020 Nov 6;142(46):19668–19677. doi: 10.1021/jacs.0c09352

Figure 7.

Figure 7.

Biocatalytic synthesis of 5-alkyl picolinic acid derivatives. Analytical HPLC chromatograms of each reactions at small scale (200 μL). Assay conditions: 2 mM OAH, 10 μM Fub7, 5 μM Fub9, 0.1 μM catalase, and 8 mM aldehydes mixed in phosphate buffer [50 mM K2HPO4 (pH 7.5), 100 mM NaCl, 3% (v/v) DMSO] and incubated at 20 °C. Five compounds (10, 11, 14–16) were isolated for structural characterization. N.D., not determined.