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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Nature. 2021 Mar 24;592(7855):596–600. doi: 10.1038/s41586-021-03369-7

Extended Data Fig. 7 |. CNO reactivates hM3Dq-expressing neurons.

Extended Data Fig. 7 |

a-d, cFos reactivation in task-specific neurons expressing mCherry or hM3Dq-mCherry. Overlap between cFos and mCherry in the cortex (a) and hippocampus (c) of mice injected with CNO in the homecage at 13 weeks of age. Quantification of mCherry+ cells and reactivation from cortex (b) and hippocampus (d) in WT (n = 4) and Rett (n = 4) mice. Scale bar, 200 μm. The sample size (n) corresponds to the number of biologically independent mice. 3–4 sections were analyzed per mouse. Data are represented as mean ± s.e.m. Statistical significance was determined using a two-way ANOVA with Tukey’s multiple comparisons test; ns (p>0.05), **** (p<0.0001).