Table 4.

Treatment-emergent adverse events by system organ class

	2012 EGKINETIC4		2012 EGKINETIC6		EGKINETIC6OP
	E2 BID	E4 OD	EC2 TID	ES6 OD	ES6 OD	E6 OD
	(N = 22)	(N = 22)	(N = 22)	(N = 22)	(N = 30)	(N = 29)
	n (%)	n (%)	n (%)	n (%)	n (%)	n (%)
Endocrine disorders	0	0	1 (4.5%)	0	0	0
Gastrointestinal disorders	3 (13.6%)	3 (13.6%)	1 (4.5%)	1 (4.5%)	0	1 (3.4%)
General disorders and administration site conditions	0	0	2 (9.1%)	1 (4.5%)	0	0
Infections and infestations	3 (13.6%)	2 (9.1%)	0	0	0	1 (3.4%)
Injury, poisoning and procedural complications	1 (4.5%)	1 (4.5%)	0	0	0	0
Metabolism and nutrition disorders	0	0	1 (4.5%)	0	0	0
Nervous system disorders	1 (4.5%)	1 (4.5%)	2 (9.1%)	3 (13.6%)	1 (3.3%)	3 (10.3%)
Reproductive system and breast disorders	2 (9.1 %)	3 (13.6%)	1 (4.5%)	1 (4.5%)	0	0
Respiratory, thoracic and mediastinal disorders	1 (4.5%)	1 (4.5%)	0	4 (18.2%)	0	0