Table 3.

Bioanalysis Platforms for Antibody Prodrugs

PDC pro-antibody drug conjugates, TCB T cell-engaging bispecific antibodies, IC-LC-MS immunocapture-liquid chromatography coupled with tandem mass spectrometry, LBA ligand binding assay, ADA anti-drug antibody, PK/TK pharmacokinetic/toxicokinetic, HRMS high-resolution mass spectrometry, DTT dithiothreitol, MSD Meso Scale Discovery, PTM posttranslational modification, DAR drug antibody ratio, RO receptor occupancy, IPT immunophenotyping, ELISA enzyme-linked immunosorbent assay