Table 1.
Demographic data, lesions at time of surgery and genetic diagnosis
| Until 2000 | 2001 and after | p | |||
|---|---|---|---|---|---|
| N = 13 | (%) | N = 18 | (%) | ||
| Sex ratio Men/total | 7/13 | 54 | 8/18 | 44 | 0.6 |
| Age at MEN1 diagnosis | 43.5 ± 15.1 | 36.9 ± 17.2 | 0.3 | ||
| Age at DP-NET diagnosis | 42.9 ± 14.5 | 42..6 ± 14.9 | 0.9 | ||
| Age at DP-NET surgery | 43. ± 14.4 | 44..4 ± 14.3 | 0.8 | ||
| DP-NET known before MEN1 diagnosis | 5/13 | 38 | 3/18 | 17 | 0.2 |
| pHPT at time of DP-NET surgery | 7/13 | 54 | 13/18 | 72 | 0.4 |
| Pituitary adenoma at time of DP-NET surgery | 1/13 | 8 | 8/18 | 44 | 0.04 |
| Adrenal at time of DP-NET surgery | 2/13 | 15 | 3/18 | 17 | 1 |
| Thymic NET at time of DP-NET surgery | 0/13 | 0 | 0/18 | 0 | 1 |
| Bronchic NET at time of DP-NET surgery | 0/13 | 0 | 0/18 | 0 | 1 |
| Previous gastric surgery | 1/13 | 8 | 0/18 | 0 | 0.4 |
| Index cases | 4/13 | 31 | 1/18 | 5 | 0.1 |
| Genetic tests performed | 10/13 | 77 | 18/18 | 100 | 0.06 |
| Positive MEN1 mutations found | 8/10 | 80 | 16/18 | 89 | 0.6 |
| Indication for ZES | 7/13 | 54 | 11/18 | 61 | 0.7 |
| Indication to control H + secretion among ZES | 7/7 | 100 | 5/11 | 45 | 0.04 |
| Indication for large non-functioning NET | 3/13 | 23 | 6/18 | 33 | 0.7 |