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. 2021 Apr 14;46(3):343–352. doi: 10.1007/s13318-021-00671-7
Population pharmacokinetic models were used to explore the pharmacokinetics of sunitinib in children with gastrointestinal stromal tumors or other solid tumors
Based on the final model, a dose of approximately 20 mg/m2/day in children with gastrointestinal stromal tumors would be expected to lead to similar levels of sunitinib as in adults receiving the daily approved dose
This study provides new data to guide sunitinib dosing in children