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. 2021 May 3;12:2491. doi: 10.1038/s41467-021-22760-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Synteny map for the genomic region flanking the genes of methylcitrate cycle (MCC) in M. kansasii. Full-length and truncated genes are represented by arrows and rectangles respectively. The full MCC genes in M. kansasii and their orthologous sequences in the other MKC species are indicated with different colors. The flanking genes are in gray or white to represent homologous or orphan genes, respectively. b A scheme of the MCC of mycobacteria and its relation to the beta-oxidation, tricarboxylic acid (TCA) and glyoxylate cycles. 2MC 2-methylcitrate, 2MI 2-methylisocitrate, OAA oxaloacetate. c Synteny map of the three ESP (ESX-1 secretory protein) loci specific to M. kansasii. Red arrows represent espE-like genes and the numbers indicate their MKAN_RS identifiers. d Sequence similarity between the EspE of M. tuberculosis and the EspE-like proteins of M. kansasii. Residues are colored to indicate similarities.