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. 2021 May 3;7:91. doi: 10.1038/s41420-021-00472-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — During osteogenic differentiation, numbers of regulators are found to modulate histone acetylation and methylation by affecting the catalytic activity of histone modifiers. The altered histone acetylation and methylation then control expression of osteogenic marker genes, directly or indirectly. HATs histone acetyltransferases, HDACs histone deacetylases, HMTs histone methyltransferases, KDMs histone demethylases, BMPs bone morphogenetic proteins, HOXs homeobox genes, Runx2 runt-related transcription factor 2, OC osteocalcin, OSX osterix, ALP alkaline phosphatase.