Table 2.
Histone methylation centric-regulation in osteogenic genes expression.
| Regulator/histone modifer | Histone modification | Target gene | Role | Reference |
|---|---|---|---|---|
| RBP2 | H3K4me3 | OC, OSX, Runx2 | Inhibited osteogenic differentiation of hASCs | 58,59 |
| BCOR | AP-2, EREG | Decreased osteo/dentinogenic potentials of MSCs | 62,63 | |
| Ash1l | OSX, Runx2, HOXA10, Sox9 | Promoted osteogenic differentiation | 65 | |
| NO66 | BSP, OC | Inhibited osteogenic differentiation of osteoprogenitor cells and mineralization | 66 | |
| KDM7A | H3K9me2 | C/ebpα, SFRP1 | Inhibited osteogenic differentiation of osteoprogenitor cells | 73 |
| KDM4B | H3K9me3 | DLX5 | Promoted osteogenic differentiation of MSCs | 69 |
| KDM4A | C/ebpα, SFRP4 | Inhibited osteogenic differentiation of osteoprogenitor cells | 74 | |
| KDM7A | H3K27me2 | C/ebpα, SFRP1 | Inhibited osteogenic differentiation of osteoprogenitor cells | 73 |
| KDM6B | H3K27me3 | HOXC6-1 | Promoted osteogenic differentiation of MSCs | 69 |
| CDK1 | HOXA7, HOXA9,Runx2, TCF7 | Promoted osteogenic differentiation of MSCs | 79 | |
| EZH2 | Runx2, OC, ZBTB16, MX1, FHL1 | Inhibited osteogenic differentiation of MSCs | 76–78 | |
| KDM6A | Runx2, OC | Promoted osteogenic differentiation of MSCs | 76 | |
| TNFα | Runx2 | Inhibited osteogenic differentiation of rMSCs | 80 | |
| DLX3 | DKK4 | Promoted osteogenic differentiation of BMSCs | 82 | |
| BCOR | H3K36me2 | AP-2, EREG | Inhibited osteogenic differentiation of MSCs | 62,63 |
| NO66 | H3K36me3 | BSP, OC | Inhibited osteogenic differentiation of preosteoblasts | 66 |