Table 3.
Histone acetylation and methylation centric-regulation in osteogenic genes expression.
| Regulator/histone modifer | Histone modification | Target gene | Role | Reference |
|---|---|---|---|---|
| NaBu | H3K9Ac, H3K9Me3 | Runx2 | Promoted osteogenic differentiation of ADSCs | 86 |
| TSA | BMP, ALP | Promoted osteogenic differentiation of nonosteogenic cells | 87 | |
| Wnt/β-catenin | H3K9Ac, H3K14Ac, H4K12Ac, H3K9Me2 | PPARγ2 | Attenuated osteogenic potential of osteoporotic BMSCs | 90 |
| HOXA10 | H4Ac, H3K4Me3 | Runx2, OC, ALP, BSP | Promoted osteogenic differentiation of osteoprogenitor cells | 92 |
| miR-23a | H3K27Ac,H3K27Me3 | OC | Promoted bone formation in mice | 77 |