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. 2021 May 3;11:262. doi: 10.1038/s41398-021-01381-z

Fig. 5. Improvement of behavioral deficits in VB6-deficient mice by guanfacine treatment.

Fig. 5

VB6(−) mice were administrated GFC during the last of 4 weeks of feeding with VB6-lacking diet. A NA turnover in the PFC were determined by HPLC. Two-way ANOVA: FInteraction(1,28) = 7.62, p < 0.05; FGFC(1,28) = 17.3, p < 0.001; FVB6(1,28) = 58.2, p < 0.001. ***p < 0.001, ###p < 0.001, and %p < 0.05 using Bonferroni’s multiple comparison test. In social interaction test, B traveled distance and C time spent in the chamber were measured (n = 12). In the novel object recognition test, D exploratory time and E exploratory preference were determined (n = 12). Two-way ANOVA: B FInteraction(3,44) = 6.86, p < 0.001; FSession(1,44) = 147.8, p < 0.001; FGroup(3,44) = 54.9, p < 0.001, C FInteraction(3,44) = 10.51, p < 0.001; FSession(1,44) = 71.7, p < 0.001; FGroup(3,44) = 1.30, p > 0.05, D FInteraction(3,44) = 4.78, p < 0.01; FSession(1,44) = 111.6, p < 0.001; FGroup(3,44) = 17.5, p < 0.001, and E FInteraction(3,44) = 1.07, p > 0.05; FSession(1,44) = 25.8, p < 0.001; FGroup(3,44) = 4.00, p < 0.05. *p < 0.05, ***p < 0.001, #p < 0.05, ##p < 0.01, %%p < 0.01, %%%p < 0.001, and &&&p < 0.001 using Bonferroni’s multiple comparison test. $$p < 0.01 compared with control/SAL mice between the habituation and the training session by Bonferroni’s multiple comparison test. The data were shown as mean ± SEM values.