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. 2021 May 3;12:2493. doi: 10.1038/s41467-021-22767-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The inter-individual and intra-individual variation of protein levels calculated as the mean coefficient of variation (CV) for each protein within each visit and across all analyzed individuals (n = 76) in the wellness cohort, and as the mean CV for each protein within each individual across all visits (n = 3), respectively. b Manhattan plots of the sentinel pQTL per protein visualizing the cis-pQTLs and trans-pQTLs for all proteins with significant associations. The light and dark grey dots represent the not significant associations split into chromosome location. c Manhattan plot of protein PNLIPRP2 shows the genome locations of all associated pQTLs. d The longitudinal protein concentration across visits one to three with each individual connected with a dotted line for PNLIPRP2, colored by the different variants. Source data are provided as a Source Data file.