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. 2021 May 3;11:9442. doi: 10.1038/s41598-021-88769-5

Figure 1.

Figure 1

Disruption of PPI is associated with compulsive grooming phenotype in Sapap3-KOs. (A) PPI (average % across 3 prepulse intensities tested) did not differ between Sapap3-KO and WT mice. (B) Time spent grooming was significantly elevated in Sapap3-KO relative to WT, as previously described. Unfilled grey symbols denote KO-L, filled grey symbols denote KO-NL. (C) Average PPI was significantly negatively correlated with time spent grooming, suggesting disruption of PPI in Sapap3-KOs with the most severe compulsive grooming phenotype. (D) When Sapap3-KOs were separated based on the presence (KO-L) or absence (KO-NL) of lesions resulting from compulsive grooming, significant disruption of PPI in KO-L was revealed relative to WT and KO-NL (Bonferroni post-hoc tests: WT vs KO-L, p = 0.006; WT vs KO-NL, p > 0.99, KO-L vs KO-NL p = 0.003). In panel A, # indicates results of unpaired Welch’s T test, in panel B * indicates results of Mann–Whitney test, in panel D * indicate results of Bonferroni post-hoc test. **** p < 0.0001; ** p < 0.01; # p = 0.10. n = 12 WT, 18 KO (10 KO-L, 8 KO-NL). PPI prepulse inhibition, KO knockout, KO-L KOs with lesions, KO-NL KOs without lesions, WT wild-type.