Table 1.

Summary statistics of low-frequency genome-wide hits identified in the study.

SNP	Chr	Position	Genes	TA	TAF	Discovery			Replication			Meta-analysis
						N = 20,177			N = 5356			N = 25,533
						Beta	Se	P	Beta	Se	P	Beta	Se	P
rs186524197	7	124431653	POT1	A	0.007	−0.360	0.059	1.32 ×  10−9	In linkage disequilibrium with rs79314063 (r2 = 0.883).
rs79314063	7	124481168	POT1	G	0.007	−0.345	0.057	1.15 ×  10−9	−0.191	0.131	0.146	−0.320	0.052	6.94 ×  10−10
rs79617270	8	73978144	TERF1/SBSPON	G	0.008	0.384	0.054	9.49 ×  10−13	0.328	0.123	0.008	0.376	0.049	2.49 ×  10−14
rs139620151	10	105593428	STN1/SH3PXD2A	A	0.006	0.383	0.067	1.17 ×  10−8	0.456	0.163	0.005	0.394	0.062	2.16 ×  10−10

Chr chromosome, TA test allele, TAF test allele frequency.