Table 4.
Association of weighted genetic risk score for increased LTL with major incident cancers in the SCHS dataset.
| Case/non-case | HR (95% Cl) | P | Padj | |
|---|---|---|---|---|
| Colorectal cancer | 654/21,531 | 1.037 (0.996, 1.081) | 0.079 | 0.553 |
| Colon cancer | 405/21,531 | 1.061 (1.007, 1.117) | 0.025 | 0.175 |
| Rectum cancer | 249/21,531 | 1.001 (0.936, 1.071) | 0.975 | 1.000 |
| Lung cancer | 496/21,531 | 1.074 (1.024, 1.125) | 0.003 | 0.021 |
| Lung adenocarcinoma | 237/21,531 | 1.123 (1.051, 1.201) | 0.001 | 0.007 |
| Non-adenocarcinoma lung cancer | 259/21,531 | 1.031 (0.965, 1.101) | 0.368 | 1.000 |
| Breast cancer | 335/12,112 | 0.999 (0.944, 1.058) | 0.979 | 1.000 |
Padj: score test P adjusted for seven tests; HR: hazard ratio; Cl: confidence interval. Padj < 0.05 values are in bold.