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. 2021 May 3;10(5):36. doi: 10.1038/s41389-021-00323-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Endogenous VEGF-A splicing patterns; terminal exon 8 alternative 3′ splicing results in the anti-angiogenic “b” isoforms. B Parts of VEGF-A gene (intron 7 and relevant regions of exon 8) have been inserted into the bichromatic reporter in such a way that splicing at the proximal splice site (PSS) of exon 8 results in formation of dsRED and then a stop codon is encountered, so EGFP is not formed. When the distal splice site (DSS) is used, there is a shift in the reading frame (dsRED + 1) and a fusion with EGFP is formed.