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. 2021 May 3;12(5):440. doi: 10.1038/s41419-021-03637-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A HOTAIR subcellular localization predicted by online analysis site. B HOTAIR distribution in K562 cells and KCL-22 c ells. C HOTAIR distribution in K562 cells and KCL-22 cells verified by FISH assay. D HOTAIR binds to methyltransferase in K562 cells tested by RIP assay. E HOTAIR binds to methyltransferase in KCL-22 cells tested by RIP assay. F The binding of DNMT1 and PTEN in K562 cells tested by ChIP assay. G The binding of DNMT1 and PTEN in KCL-22 cells tested by ChIP assay. H PTEN methylation level in K562 ce lls tested by MSP. I PTEN methylation level in KCL-22 cells tested by MSP. In RIP assay, *P < 0.05 vs. the IgG group. In ChIP assay, *P < 0.05 vs. the sh-NC group. N = 3. Measurement data were depicted as mean ± standard deviation. Comparisons between two groups were conducted by independent sample t-test, and comparison among multiple groups were assessed by one-way ANOVA followed by Tukey’s multiple comparisons test.