Table 3.
Radiomics features demonstrating a significant difference between triple negative breast cancers (TNBC) with and without pathological complete response (pCR)
| Radiomics feature | No pCR (n=47) Median (range) | pCR (n=27) Median (range) | p value | AUC (CI) |
|---|---|---|---|---|
| Entropy (SSF=0 mm) | 7.05 (6.03, 7.63) | 6.88 (3.39, 7.27) | 0.049 | 0.64 (0.51–0.77) |
| Mean signal intensity (SSF= 2 mm) | −0.01 (−0.03, −0.00) | 0.00 (−0.03, −0.00) | 0.009 | 0.68 (0.55–0.82) |
| Mean signal intensity (SSF= 4 mm) | −0.022 (−0.11, −0.01) | −0.017 (−0.13, −0.01) | 0.02 | 0.67 (0.53–0.80) |
| Median signal intensity (SSF= 2 mm) | −0.01 (−0.03, −0.00) | 0.00 (−0.04, −0.00) | 0.03 | 0.66 (0.52–0.79) |
| Maximum signal intensity (SSF= 0 mm) | 2156 (1048, 3674) | 1820 (1053, 2869) | 0.03 | 0.65 (0.51–0.79) |
| Maximum signal intensity (SSF= 2 mm) | 0.11 (0.04, 0.22) | 0.07 (0.03, 0.16) | 0.02 | 0.66 (0.53–0.79) |
| Minimum signal intensity (SSF= 2 mm) | −0.14 (−0.46, −0.05) | −0.11 (−0.26, −0.04) | 0.01 | 0.67 (0.55–0.8) |
| Minimum signal intensity (SSF= 4 mm) | −0.29 (−0.62, −0.12) | −0.22 (−0.45, −0.13) | 0.007 | 0.69 (0.57–0.82) |
| Minimum signal intensity (SSF= 6 mm) | −0.27 (−0.54, −0.12) | −0.20 (−0.43, −0.13) | 0.004 | 0.7 (0.57–0.83) |
| Standard deviation of intensity (SSF=0 mm) | 273.85 (136.75, 426.75) | 225.16 (108.92, 350.09) | 0.009 | 0.68 (0.55–0.82) |
| Standard deviation of intensity (SSF=2 mm) | 0.02 (0.01, 0.05) | 0.01 (0.01, 0.04) | 0.004 | 0.70 (0.57–0.84) |
| Standard deviation of intensity (SSF=4 mm) | 0.05 (0.03, 0.13) | 0.04 (0.02, 0.09) | <0.001 | 0.73 (0.61–0.85) |
| Standard deviation of intensity (SSF=6 mm) | 0.05 (0.03, 0.13) | 0.04 (0.02, 0.12) | <0.001 | 0.73 (0.61–0.86) |
SSF=spatial scaling factor, AUC=area under the curve, CI=confidence interval