Table 4.

ADME properties of molecules

Reference range	Solute molecular weight	QPlogHERG	QPPCaco (nm/s)	QPPMDCK (nm/s)	RuleOfFive	RuleOfThree
	130–725	(concern below − 5)	a < 25 is poor and a > 500 is great	a < 25 is poor and a > 500 is great	Maximum is 4	Maximum is 3
3a	237	− 5.56	971	479	0	0
3b	237	− 5.64	970	479	0	0
3c	237	− 5.63	970	479	0	0
3d	253	− 5.67	971	479	0	0
3e	253	− 5.57	970	479	0	0
3f	253	− 5.55	970	479	0	0
3g	258	− 5.6	971	1050	0	0
3h	258	− 5.63	970	1180	0	0
3i	258	− 5.62	970	1181	0	0
3j	302	− 5.62	971	1130	0	0
3k	302	− 5.66	970	1269	0	0
3l	302	− 5.65	970	1269	0	0
3m	229	− 5.32	969	884	0	0
3n	213	− 5.09	968	478	0	0
3o	223	− 5.68	971	479	0	0