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. 2021 Mar 17;6(4):365–380. doi: 10.1016/j.jacbts.2021.01.001

Figure 7.

Figure 7

FYCO1 Overexpression Blunts Cardiac Dysfunction Due to Pressure Overload

FYCO1 TG and WT mice were subjected to transverse aortic constriction (TAC) for 2 weeks. (A) LV mass/body weight and (B) lung weight as a marker of congestive heart failure after TAC. (C) Echocardiographic analysis of ejection fraction after TAC. (D) Expression of Nppa/ANF and Nppb/BNP by qPCR in left ventricles of banded TG and WT mice. (E) Expression of autophagic proteins LC3-II, p62, Rab7, and beclin-1 in left ventricles of banded TG and WT animals. All datasets are presented as dot plots with mean ± SEM (2-way ANOVA followed by Student-Newman-Keuls post hoc tests). ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001. Abbreviations as in Figures 1, 4, and 5.