Table 4.
Patient Levels of Markers of Intestinal Barrier Dysfunction
| CPB Patients |
Control Subjects |
p Value∗ | |||
|---|---|---|---|---|---|
| n | Value | n | Value | ||
| FABP2 pre-surgery | 14 | 1.80 (1.32 to 2.46) | 9 | 1.58 (0.97 to 1.98) | 0.12 |
| FABP2 24 h post-surgery | 14 | 3.08 (2.14 to 4.29) | 9 | 1.65 (1.20 to 2.14) | 0.001 |
| FABP2 48 h post-surgery | 11 | 2.27 (1.85 to 3.93) | 6 | 1.20 (0.80 to 1.74) | 0.002 |
| FABP2 Δ 24 h | 14 | 1.06 (0.55 to 2.18) | 9 | 0.14 (0.08 to 0.28) | <0.001 |
| FABP2 Δ 48 h | 11 | 0.88 (−0.12 to 1.84) | 6 | −0.21 (−0.97 to −0.08) | 0.022 |
| Claudin-3 pre-surgery | 14 | 0.35 (0.21 to 0.45) | 9 | 0.37 (0.17 to 0.45) | 0.93 |
| Claudin-3 24 h post | 14 | 0.55 (0.47 to 1.00) | 9 | 0.43 (0.20 to 0.53) | 0.028 |
| Claudin-3 48 h post-surgery | 11 | 1.62 (1.24 to 1.78) | 6 | 0.22 (0.20 to 0.59) | <0.001 |
| Claudin-3 Δ 24 h | 14 | 0.26 (0.09 to 0.57) | 9 | 0.06 (0.02 to 0.08) | 0.004 |
| Claudin-3 Δ 48 h | 11 | 1.04 (0.89 to 1.67) | 6 | 0.06 (0.01 to 0.21) | <0.001 |
| Citrulline pre-surgery | 14 | 34.5 ± 8.9 | 9 | 28.8 ± 3.6 | 0.08 |
| Citrulline 24 h post-surgery | 14 | 15.4 ± 4.2 | 9 | 19.7 ± 5.0 | 0.041 |
| Citrulline 48 h post-surgery | 11 | 12.5 ± 3.2 | 6 | 17.7 ± 6.9 | 0.043 |
| Citrulline Δ 24 h | 14 | −19.1 ± 7.4 | 9 | −9.1 ± 4.3 | 0.001 |
| Citrulline Δ 48 h | 11 | −22.1 ± 9.5 | 6 | −12.0 ± 5.9 | 0.035 |
Values are median (interquartile range) or mean ± SD.
CPB = cardiopulmonary bypass; FABP2 = fatty acid binding protein 2.
∗
Student’s t-test and the Mann-Whitney U was test were used for normally and non-normally distributed data, respectively.