FIG 2.

Cells with Nrf2 deleted are maintained stably in the esophageal epithelium for weeks. (A) Experimental schedule after Tam administration. (B) Recombination rate of the Nrf2 gene in the esophageal epithelium. The remaining Nrf2 DNA was quantified after deletion by Tam (n = 4 to 6). (C) mRNA expression levels of Nrf2 and the target gene, Nqo1 (n = 3 to 6). Data represent the mean ± SD. These data were analyzed using Student's t test. *, P < 0.05, and **, P < 0.01, compared with the Nrf2^F/F mice at each time point.