Table 2.

Observational studies that address discontinuation of psychostimulants in children with ADHD.

Reference	Industry sponsored	Duration of medication discontinuation	Total N	Age	Number of boys (% of total)	Medication(s)	Primary outcome measure(s)	Findings
Hoare and Sevar (27)	NR	>24 h	15	4.5–14.6	100%	MPH	Primary: CANTAB SNAP-IV	Compared to testing with MPH, youth performed worse on placebo for some test measures (pattern recognition, spatial working memory, intra/extra dimensional set-shifting) primarily relating to executive function, though no effect was noted on other measures. All except one youth had worse SNAP scores on placebo.
Sleator (28)	NR	“Within patient” design, 1 month each of three different drug doses and PBO	42; only 28 received PBO trial	NR	NR	MPH	Conners' teacher's abbreviated symptom questionnaire (ASQ) remission defined as <15	17/42 (40%) showed significant deterioration during PBO; 11/41 (26%) showed no deterioration on PBO

CANTAB, Cambridge Neuropsychological Test Automated Battery; Conners' ASQ, Conners Teacher's Abbreviated Symptom Questionnaire; NR, not reported.