Table 1.

PICOS strategy for clinical evidence.

PICOS	Clinical Review
Population	Patients with oral candidiasis
Intervention	Clotrimazole used in treating oral candidiasis regardless of dosage regimen
Comparator	Placebo or other antifungal therapies
Outcome	Clinical response, mycological cure, relapse rate, and adverse outcomes
Study design	Published or unpublished randomized controlled trials of any size and duration