Table 4.
Meta-analysis of the efficacy of clotrimazole.
| Control | Clinical response |
Mycological cure |
Relapse |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of studies | No. of patients | OR (95% CI) | I2 (%) | No. of studies | No. of patients | OR (95% CI) | I2 (%) | No. of studies | No. of patients | OR (95% CI) | I2 (%) | |
| Placebo | 2 | 33 | 61.63 (6.95–546.12) | 0 | 2 | 33 | 27.83 (3.15–246.12) | 0 | – | – | – | – |
| Fluconazole | 4 | 426 | 0.23 (0.09–0.57) | 0 | 4 | 384 | 0.40 (0.26–0.61) | 21.4 | 4 | 271 | FEM: 2.04 (1.17–3.55) REM: 3.45 (1.06–11.30) |
52.9 |
| Other topical and systemic agents | 10* | 1388 | 0.85 (0.65–1.11) | 45 | 9 | 1287 | FEM: 0.62 (0.49–0.79) REM: 0.56 (0.36–0.88) |
58.1 | 10* | 918 | 1.46 (1.08–1.97) | 17.6 |
| Other topical agents | 3* | 702 | 1.20 (0.87–1.67) | 0 | 2 | 643 | 0.93 (0.66–1.32) | 0 | 3* | 475 | 1.11 (0.73–1.70) | 0 |
FEM = fixed-effects model; REM = random-effects model.
*one of the studies was divided into 2 comparisons.