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Synthesis of a N3' → P5' phosphoramidate linkage by solid-phase synthesis. (a) dichloroacetic acid; (b) ClP(NiPr2)(OCE); (c) tetrazole/water; (d) triethylamine/carbon tetrachloride; (e) repeat steps a–d; (f) detritylate then deprotect with NH3. DMT = dimethoxytrityl, CPG = succinyl-linked long chain alkylamine controlled pore glass solid support, CE = 2-cyanoethyl. Adapted from [64].
