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Synthesis of the 4'-F-rU phosphoramidite. (a) AgF, I2, dichloromethane, tetrahydrofuran; (b) NH3, methanol; (c) TBS-Cl, AgNO3, pyridine, tetrahydrofuran; (d) acetic anhydride, dimethylaminopyridine, pyridine; (e) tetrabutylammonium hydroxide, trifluoroacetic acid, m-chloroperoxybenzoic acid; (f) (i) NH3, methanol (ii) DMTCI, pyridine; (g) ClP(NiPr2)(OCE), 1-methylimidazole, (iPr2)2NEt, dichloromethane. TBS = tert-butyldimethylsilyl. Adapted from [211].
