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Synthesis of the thymine FHNA phosphoramidite. (a) thymine, 1,8-diazabicyclo[5.4.0]undec-7-ene, acetonitrile; (b) methanesulfonyl chloride, pyridine; (c) aq NaOH, 1,4-dioxane; (d) nonafluorobutanesulfonyl fluoride, 1,8-diazabicyclo[5.4.0]undec-7-ene, tetrahydrofuran; (e) H2, Pd(OH)2/C, methanol; (f) DMTCI, pyridine; (g) P(NiPr2)2(OCE), 1H-tetrazole, NMI, DMF. Ms = methanesulfonyl, Ph = phenyl, T = thymine. Adapted from [221].
