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. 2021 Apr 28;17:908–931. doi: 10.3762/bjoc.17.76

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Copyright © 2021, Liczner et al.

This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions.

The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms/terms)

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Structures of the chemically modified oligonucleotides (A) N3' → P5' phosphoramidate linkage, (B) amide (AM1) linkage, (C) phosphorodithioate (PS2), (D) glycol nucleic acid (R-isomer), (E) 2'-O-alkyl modifications (R = -CH₃, -CH₂CH₂OCH₃), (F) locked nucleic acids (LNA)/bridged nucleic acids (BNA), (G) arabinose (ANA) and arabinofluoro (FANA) nucleic acids, (H) C4'-modified nucleic acids, (I) 3'-fluorohexitol nucleic acid, (J) ribo-difluorotoluyl-modified nucleic acid.