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Crystal structures of (A) N3' → P5' phosphoramidate DNA (PDB ID 363D) [71] and (B) amide (AM1) RNA in complex with Bacillus halodurans RNase H (PDB ID 5VAJ) [73]. The relative orientation of the N3' n and P–O5' σ* orbitals in the backbone of 3'-NP DNA are consistent with an anomeric effect. The 3'-nitrogen is H-bonded to a chloride anion (green sphere) and the phosphate group forms a salt bridge to ammonium. Water molecules are cyan spheres and H-bonds are drawn with thin lines.
