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Surface models of the crystal structures of RNA dodecamers with single (A) (S)-GNA-T (PDB ID 5V1L) [54] and (B) (R)-GNA-T (PDB ID 5V1K) [54] nucleotides per strand. The presence of the (R)-GNA isomer introduces a kink in the backbone and causes local disruption of base stacking, in-line with a significantly reduced Tm relative to the (S)-GNA isomer.
