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. 2021 Apr 28;17:908–931. doi: 10.3762/bjoc.17.76

Figure 6.

Figure 6

Structure of 2'-O-(2-methoxyethyl)-RNA (MOE-RNA). (A) View into the minor groove of an A-form DNA decamer with single MOE-T nucleotides per strand (PDB ID 411D, highlighted with green carbon atoms) [120]. Water molecules are trapped in a chelate-like manner between the O3', O2' and OC' (outer oxygen of the MOE substituent). (B) and (C) individual nucleotides from a crystal structure of an MOE-RNA dodecamer duplex (PDB ID 469D) [58]. Of the 24 MOE substituents, 22 adopt a gauche conformation, either g+ or g−, whereby both trap a water molecule that can be linked to the 3'-phosphate via a water bridge.