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. 2021 Apr 20;12:667084. doi: 10.3389/fmicb.2021.667084

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Copyright © 2021 Li, Li, Liu, Chen, Jiao, Feng, Wei, Wang, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathogenicity analysis of PEDV isolates in new-born piglets. (A) Survival rate of piglets in each group. (B) The severity of diarrhea was scored based on clinical examination; 0 = normal and no diarrhea; 1, mild and fluidic diarrhea; 2, severe watery diarrhea; with scores of 1 or more considered diarrheic. (C) Fecal virus shedding in PEDV-challenged piglets by RT-qPCR. (D) Microscopic damage in Jejunum in piglets (Original magnifications: ×20). (E) Further analysis of jejunum villous high: crypt depth ratios (VH:CD).