Table 1.
CTS and groups under investigation | Values, nM | References |
---|---|---|
Ouabain | ||
Humans EH/PA/control | 3.39 ± 0.57/4.09 ± 1.12/0.53 ± 0.10 | 110 |
Humans CHF/control | 0.030–8.3/0.16–0.77 | 111 |
Humans CHF/control before HPLC | 0.25–1.6/0.13–0.56 | 28 |
Humans CHF/control after HPLC | ND/ND | 28 |
MHS/MNS | 0.076 ± 0.029/0.027 ± 0.014 | 112 |
NaCl-loaded rats/control | 1.43 ± 0.06/1.14 ± 0.05 | 113 |
ACTH-treated subjects/control | 0.87 ± 0.25/0.64 ± 0.17 | 114 |
ACTH-treated rats/control | 0.09 ± 0.01/0.10 ± 0.04 | 115 |
Humans: CRF/EH/PA/control | 0.14 ± 0.02/0.13 ± 0.05/0.10 ± 0.03/0.09 ± 0.02 | 116 |
Humans: preeclampsia/control | 0.70 ± 0.16/0.32 ± 0.07 | 117 |
3rd trimester of pregnancy/control | 0.024 ± 0.004/0.009 ± 0.001 | 118 |
Mild EH/control | 0.039 ± 0.024/0.029 ± 0.018 | 119 |
DS, high/low-NaCl diet | 0.12 ± 0.02/0.10 ± 0.02 | 120,121 |
Rats, high/normal NaCl intake | 0.28 ± 0.04/0.34 ± 0.06 | 122 |
Humans: volume expansion/control | 0.21 ± 0.04/0.09 ± 0.02 | 121 |
Dogs: controls | 0.138 ± 0.043 | 7 |
Humans: controls | 0.037 ± 0.007 | 7 |
Humans: nephrectomy/control | 0.20 ± 0.06/0.12 ± 0.06 | 123 |
Humans: mild hypertension/control | 1.34 ± 0.91/0.38 ± 0.31 | 124 |
Humans: control | 0.152 ± 0.067 | 125 |
Humans: low-renin EH/control | 0.94 ± 0.22/0.37 ± 0.04 | 126 |
Marinobufagenin | ||
ACTH-treated rats/control | 0.44 ± 0.06/0.21 ± 0.05 | 115 |
Patients with CRF/EH/PA/control | 16.6 ± 5.3/1.7 ± 0.7/13.5 ± 12.9/0.26 ± 0.05 | 116 |
Patients with preeclampsia/control | 2.63 ± 0.10/0.63 ± 0.07 | 117 |
DS, high/low-NaCl diet | 1.24 ± 0.0.27/0.38 ± 0.04 | 120,121 |
Patients with CHF stage IV/stage I | 1.90 ± 0.04/0.60 ± 0.14 | 127 |
Rats, high/normal-NaCl intake | 1.14 ± 0.12/0.55 ± 0.06 | 122 |
Patients with AMI/control | 1.9 ± 0.38/0.38 ± 0.01 | 13 |
Rats with volume expansion/control | 0.49 ± 0.05/0.20 ± 0.06 | 121 |
Patients with nephrectomy/control | 0.57 ± 0.04/0.36 ± 0.02 | 128 |
Patients: 24-hr low/high salt diet | 0.16–0.30/0.18–0.37 | 108 |
Abbreviations: AMI – acute myocardial ischemia; CHF – congestive heart failure; CRF – chronic renal failure; DS – Dahl salt-sensitive rats; EH – essential hypertension; HPLC – high-performance liquid chromatography; MHS and MNS – Milan hypertensive and normotensive strains, respectively; ND – non detectable; PA - primary aldosteronism.