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. 2020 Jan 22;8(3):259–271. doi: 10.1016/j.gendis.2020.01.008

Table 1.

Plasma levels of CTS in hypertension and states associated with sodium loading and/or plasma volume expansion and estimated by immunoassay technique.

CTS and groups under investigation Values, nM References
Ouabain
Humans EH/PA/control 3.39 ± 0.57/4.09 ± 1.12/0.53 ± 0.10 110
Humans CHF/control 0.030–8.3/0.16–0.77 111
Humans CHF/control before HPLC 0.25–1.6/0.13–0.56 28
Humans CHF/control after HPLC ND/ND 28
MHS/MNS 0.076 ± 0.029/0.027 ± 0.014 112
NaCl-loaded rats/control 1.43 ± 0.06/1.14 ± 0.05 113
ACTH-treated subjects/control 0.87 ± 0.25/0.64 ± 0.17 114
ACTH-treated rats/control 0.09 ± 0.01/0.10 ± 0.04 115
Humans: CRF/EH/PA/control 0.14 ± 0.02/0.13 ± 0.05/0.10 ± 0.03/0.09 ± 0.02 116
Humans: preeclampsia/control 0.70 ± 0.16/0.32 ± 0.07 117
3rd trimester of pregnancy/control 0.024 ± 0.004/0.009 ± 0.001 118
Mild EH/control 0.039 ± 0.024/0.029 ± 0.018 119
DS, high/low-NaCl diet 0.12 ± 0.02/0.10 ± 0.02 120,121
Rats, high/normal NaCl intake 0.28 ± 0.04/0.34 ± 0.06 122
Humans: volume expansion/control 0.21 ± 0.04/0.09 ± 0.02 121
Dogs: controls 0.138 ± 0.043 7
Humans: controls 0.037 ± 0.007 7
Humans: nephrectomy/control 0.20 ± 0.06/0.12 ± 0.06 123
Humans: mild hypertension/control 1.34 ± 0.91/0.38 ± 0.31 124
Humans: control 0.152 ± 0.067 125
Humans: low-renin EH/control 0.94 ± 0.22/0.37 ± 0.04 126
Marinobufagenin
ACTH-treated rats/control 0.44 ± 0.06/0.21 ± 0.05 115
Patients with CRF/EH/PA/control 16.6 ± 5.3/1.7 ± 0.7/13.5 ± 12.9/0.26 ± 0.05 116
Patients with preeclampsia/control 2.63 ± 0.10/0.63 ± 0.07 117
DS, high/low-NaCl diet 1.24 ± 0.0.27/0.38 ± 0.04 120,121
Patients with CHF stage IV/stage I 1.90 ± 0.04/0.60 ± 0.14 127
Rats, high/normal-NaCl intake 1.14 ± 0.12/0.55 ± 0.06 122
Patients with AMI/control 1.9 ± 0.38/0.38 ± 0.01 13
Rats with volume expansion/control 0.49 ± 0.05/0.20 ± 0.06 121
Patients with nephrectomy/control 0.57 ± 0.04/0.36 ± 0.02 128
Patients: 24-hr low/high salt diet 0.16–0.30/0.18–0.37 108

Abbreviations: AMI – acute myocardial ischemia; CHF – congestive heart failure; CRF – chronic renal failure; DS – Dahl salt-sensitive rats; EH – essential hypertension; HPLC – high-performance liquid chromatography; MHS and MNS – Milan hypertensive and normotensive strains, respectively; ND – non detectable; PA - primary aldosteronism.