Table 2. Local and systemic reactions in the ChAdOx1 group according to sex and age groups.
| Variables | Sex | P | Age group | P for trend | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Female (n = 4,302) | Male (n = 1,287) | 20s (n = 1,598) | 30s (n = 1,764) | 40s (n = 1,463) | 50s (n = 701) | 60s (n = 63) | |||||
| Adverse reactions | |||||||||||
| Any | 4,088 (95.0) | 1,129 (87.7) | < 0.001 | 1,533 (95.9) | 1,694 (96.0) | 1,359 (92.9) | 590 (84.2) | 41 (65.1) | < 0.001 | ||
| Local reactions | |||||||||||
| Pain | 3,633 (84.4) | 903 (70.2) | < 0.001 | 1,396 (87.4) | 1,509 (85.5) | 1,147 (78.4) | 454 (64.8) | 30 (47.6) | < 0.001 | ||
| Itch | 1,013 (23.5) | 229 (17.8) | < 0.001 | 478 (29.9) | 411 (23.3) | 254 (17.4) | 94 (13.4) | 5 (7.9) | < 0.001 | ||
| Redness | 340 (7.9) | 53 (4.1) | < 0.001 | 150 (9.4) | 113 (6.4) | 86 (5.9) | 40 (5.7) | 4 (6.3) | < 0.001 | ||
| Swelling | 471 (10.9) | 63 (4.9) | < 0.001 | 188 (11.8) | 152 (8.6) | 130 (8.9) | 60 (8.6) | 4 (6.3) | 0.004 | ||
| Systemic reactions | |||||||||||
| Fever | 2,352 (54.7) | 513 (39.9) | < 0.001 | 1,047 (65.5) | 1,050 (59.5) | 599 (40.9) | 159 (22.7) | 10 (15.9) | < 0.001 | ||
| Chills | 2,953 (68.6) | 727 (56.5) | < 0.001 | 1,218 (76.2) | 1,287 (73.0) | 839 (57.3) | 321 (45.8) | 15 (23.8) | < 0.001 | ||
| Muscle ache | 3,548 (82.5) | 918 (71.3) | < 0.001 | 1,386 (86.7) | 1,477 (83.7) | 1,128 (77.1) | 450 (64.2) | 25 (39.7) | < 0.001 | ||
| Joint pain | 2,209 (51.3) | 507 (39.4) | < 0.001 | 870 (54.4) | 899 (51.0) | 679 (46.4) | 258 (36.8) | 10 (15.9) | < 0.001 | ||
| Headache | 3,172 (73.7) | 715 (55.6) | < 0.001 | 1,329 (83.2) | 1,308 (74.1) | 899 (61.4) | 335 (47.8) | 16 (25.4) | < 0.001 | ||
| Dizziness | 2,139 (49.7) | 476 (37.0) | < 0.001 | 952 (59.6) | 881 (49.9) | 576 (39.4) | 197 (28.1) | 9 (14.3) | < 0.001 | ||
| Confused mentality | 845 (19.6) | 220 (17.1) | 0.045 | 459 (28.7) | 354 (20.1) | 188 (12.9) | 60 (8.6) | 4 (6.3) | < 0.001 | ||
| Anxiety | 1,012 (23.5) | 242 (18.8) | < 0.001 | 513 (32.1) | 416 (23.6) | 233 (15.9) | 87 (12.4) | 5 (7.9) | < 0.001 | ||
| Dyspepsia | 1,397 (32.5) | 328 (25.5) | < 0.001 | 638 (39.9) | 599 (34.0) | 365 (24.9) | 113 (16.1) | 10 (15.9) | < 0.001 | ||
| Abdominal pain | 1,106 (25.7) | 254 (19.7) | < 0.001 | 557 (34.9) | 459 (26.0) | 252 (17.2) | 86 (12.3) | 6 (9.5) | < 0.001 | ||
| Vomiting | 1,039 (24.2) | 234 (18.2) | < 0.001 | 521 (32.6) | 433 (24.5) | 241 (16.5) | 73 (10.4) | 5 (7.9) | < 0.001 | ||
| Diarrhea | 1,075 (25.0) | 272 (21.1) | 0.005 | 552 (34.5) | 462 (26.2) | 256 (17.5) | 70 (10.0) | 7 (11.1) | < 0.001 | ||
| Fatigue | 3,408 (79.2) | 869 (67.5) | < 0.001 | 1,360 (85.1) | 1,456 (82.5) | 1,026 (70.1) | 409 (58.3) | 26 (41.3) | < 0.001 | ||
| Palpitation | 1,313 (30.5) | 268 (20.8) | < 0.001 | 653 (40.9) | 531 (30.1) | 302 (20.6) | 89 (12.7) | 6 (9.5) | < 0.001 | ||
| Hypertension | 812 (18.9) | 201 (15.6) | 0.009 | 430 (26.9) | 346 (19.6) | 177 (12.1) | 56 (8.0) | 4 (6.3) | < 0.001 | ||
| Hypotension | 812 (18.9) | 196 (15.2) | 0.003 | 440 (27.5) | 341 (19.3) | 168 (11.5) | 55 (7.8) | 4 (6.3) | < 0.001 | ||
| Paralysis | 797 (18.5) | 195 (15.2) | 0.006 | 428 (26.8) | 339 (19.2) | 171 (11.7) | 51 (7.3) | 3 (4.8) | < 0.001 | ||
| Paraesthesia | 871 (20.2) | 210 (16.3) | 0.002 | 453 (28.3) | 371 (21.0) | 195 (13.3) | 59 (8.4) | 3 (4.8) | < 0.001 | ||
| Nasal obstruction | 1,227 (28.5) | 292 (22.7) | < 0.001 | 596 (37.3) | 507 (28.7) | 307 (21.0) | 105 (15.0) | 4 (6.3) | < 0.001 | ||
| Angioedema | 862 (20.0) | 207 (16.1) | 0.002 | 451 (28.2) | 368 (20.9) | 185 (12.6) | 62 (8.8) | 3 (4.8) | < 0.001 | ||
| Tongue edema | 812 (18.9) | 196 (15.2) | 0.003 | 436 (27.3) | 347 (19.7) | 171 (11.7) | 51 (7.3) | 3 (4.8) | < 0.001 | ||
| Parageusia | 385 (8.9) | 65 (5.1) | < 0.001 | 165 (10.3) | 131 (7.4) | 111 (7.6) | 42 (6.0) | 1 (1.6) | < 0.001 | ||
| Foreign body sensation in the throat | 1,079 (25.1) | 281 (21.8) | 0.019 | 455 (28.5) | 464 (26.3) | 315 (21.5) | 120 (17.1) | 6 (9.5) | < 0.001 | ||
| Throat swelling and tightness | 935 (21.7) | 243 (18.9) | 0.031 | 404 (25.3) | 401 (22.7) | 278 (19.0) | 90 (12.8) | 5 (7.9) | < 0.001 | ||
| Hoarseness | 464 (10.8) | 116 (9.0) | 0.076 | 219 (13.7) | 180 (10.2) | 121 (8.3) | 56 (8.0) | 4 (6.3) | < 0.001 | ||
| Odynophagia | 506 (11.8) | 109 (8.5) | 0.001 | 246 (15.4) | 200 (11.3) | 119 (8.1) | 48 (6.8) | 2 (3.2) | < 0.001 | ||
| Wheezing | 291 (6.8) | 67 (5.2) | 0.053 | 167 (10.5) | 109 (6.2) | 56 (3.8) | 25 (3.6) | 1 (1.6) | < 0.001 | ||
| Chest discomfort | 290 (6.7) | 63 (4.9) | 0.02 | 156 (9.8) | 114 (6.5) | 59 (4.0) | 22 (3.1) | 2 (3.2) | < 0.001 | ||
| Urticaria | 272 (6.3) | 50 (3.9) | 0.001 | 146 (9.1) | 101 (5.7) | 59 (4.0) | 16 (2.3) | 0 (0) | < 0.001 | ||
| Skin rash | 277 (6.4) | 43 (3.3) | < 0.001 | 137 (8.6) | 100 (5.7) | 61 (4.2) | 22 (3.1) | 0 (0) | < 0.001 | ||
| Antipyretic use | 3,627 (84.3) | 970 (75.4) | < 0.001 | 1,396 (87.4) | 1,506 (85.4) | 1,156 (79.0) | 505 (72.0) | 34 (54.0) | < 0.001 | ||
Data are presented as number (%).