Table 3. Local and systemic reactions in the BNT162b2 group according to sex and age groups.
| Variables | Sex | P | Age group | P for trend | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Female (n = 185) | Male (n = 92) | 20s (n = 87) | 30s (n = 103) | 40s (n = 35) | 50s (n = 24) | 60s (n = 28) | |||||
| Adverse reactions | |||||||||||
| Any | 156 (84.3) | 66 (71.7) | 0.02 | 74 (85.1) | 83 (80.6) | 30 (85.7) | 15 (62.5) | 20 (71.4) | 0.03 | ||
| Local reactions | |||||||||||
| Pain | 136 (73.5) | 58 (63.0) | 0.098 | 70 (80.5) | 73 (70.9) | 25 (71.4) | 13 (54.2) | 13 (46.4) | < 0.001 | ||
| Itch | 12 (6.5) | 5 (5.4) | 0.94 | 10 (11.5) | 5 (4.9) | 0 (0) | 2 (8.3) | 0 (0) | 0.03 | ||
| Redness | 6 (3.2) | 1 (1.1) | 0.50 | 3 (3.4) | 2 (1.9) | 1 (2.9) | 1 (4.2) | 0 (0) | 0.54 | ||
| Swelling | 11 (5.9) | 3 (3.3) | 0.50 | 5 (5.7) | 5 (4.9) | 1 (2.9) | 2 (8.3) | 1 (3.6) | 0.82 | ||
| Systemic reactions | |||||||||||
| Fever | 15 (8.1) | 4 (4.3) | 0.36 | 11 (12.6) | 6 (5.8) | 1 (2.9) | 0 (0) | 1 (3.6) | 0.02 | ||
| Chills | 34 (18.4) | 10 (10.9) | 0.15 | 15 (17.2) | 21 (20.4) | 4 (11.4) | 3 (12.5) | 1 (3.6) | 0.06 | ||
| Muscle ache | 63 (34.1) | 30 (32.6) | 0.92 | 33 (37.9) | 38 (36.9) | 10 (28.6) | 4 (16.7) | 8 (28.6) | 0.07 | ||
| Joint pain | 16 (8.6) | 10 (10.9) | 0.71 | 12 (13.8) | 10 (9.7) | 3 (8.6) | 1 (4.2) | 0 (0) | 0.02 | ||
| Headache | 51 (27.6) | 16 (17.4) | 0.087 | 33 (37.9) | 23 (22.3) | 7 (20.0) | 2 (8.3) | 2 (7.1) | < 0.001 | ||
| Dizziness | 29 (15.7) | 11 (12.0) | 0.52 | 17 (19.5) | 17 (16.5) | 2 (5.7) | 3 (12.5) | 1 (3.6) | 0.02 | ||
| Confused mentality | 5 (2.7) | 5 (5.4) | 0.42 | 6 (6.9) | 3 (2.9) | 0 (0) | 1 (4.2) | 0 (0) | 0.08 | ||
| Anxiety | 6 (3.2) | 7 (7.6) | 0.19 | 6 (6.9) | 4 (3.9) | 0 (0) | 2 (8.3) | 1 (3.6) | 0.54 | ||
| Dyspepsia | 12 (6.5) | 5 (5.4) | 0.94 | 10 (11.5) | 4 (3.9) | 0 (0) | 2 (8.3) | 1 (3.6) | 0.12 | ||
| Abdominal pain | 7 (3.8) | 6 (6.5) | 0.48 | 7 (8.0) | 4 (3.9) | 0 (0) | 1 (4.2) | 1 (3.6) | 0.20 | ||
| Vomiting | 10 (5.4) | 7 (7.6) | 0.65 | 9 (10.3) | 7 (6.8) | 0 (0) | 1 (4.2) | 0 (0) | 0.02 | ||
| Diarrhea | 9 (4.9) | 7 (7.6) | 0.52 | 8 (9.2) | 5 (4.9) | 0 (0) | 3 (12.5) | 0 (0) | 0.18 | ||
| Fatigue | 74 (40.0) | 30 (32.6) | 0.29 | 39 (44.8) | 38 (36.9) | 14 (40.0) | 7 (29.2) | 6 (21.4) | 0.02 | ||
| Palpitation | 7 (3.8) | 5 (5.4) | 0.75 | 7 (8.0) | 4 (3.9) | 0 (0) | 1 (4.2) | 0 (0) | 0.049 | ||
| Hypertension | 5 (2.7) | 5 (5.4) | 0.42 | 6 (6.9) | 3 (2.9) | 0 (0) | 1 (4.2) | 0 (0) | 0.08 | ||
| Hypotension | 5 (2.7) | 5 (5.4) | 0.42 | 6 (6.9) | 3 (2.9) | 0 (0) | 1 (4.2) | 0 (0) | 0.08 | ||
| Paralysis | 5 (2.7) | 5 (5.4) | 0.42 | 6 (6.9) | 3 (2.9) | 0 (0) | 1 (4.2) | 0 (0) | 0.08 | ||
| Paraesthesia | 7 (3.8) | 5 (5.4) | 0.75 | 7 (8.0) | 4 (3.9) | 0 (0) | 1 (4.2) | 0 (0) | 0.049 | ||
| Nasal obstruction | 9 (4.9) | 7 (7.6) | 0.52 | 9 (10.3) | 5 (4.9) | 1 (2.9) | 1 (4.2) | 0 (0) | 0.03 | ||
| Angioedema | 6 (3.2) | 6 (6.5) | 0.34 | 7 (8.0) | 4 (3.9) | 0 (0) | 1 (4.2) | 0 (0) | 0.049 | ||
| Tongue edema | 5 (2.7) | 5 (5.4) | 0.42 | 6 (6.9) | 3 (2.9) | 0 (0) | 1 (4.2) | 0 (0) | 0.08 | ||
| Parageusia | 4 (2.2) | 0 (0) | 0.38 | 2 (2.3) | 0 (0) | 2 (5.7) | 0 (0) | 0 (0) | 0.65 | ||
| Foreign body sensation in the throat | 21 (11.4) | 6 (6.5) | 0.29 | 13 (14.9) | 10 (9.7) | 4 (11.4) | 0 (0) | 0 (0) | 0.01 | ||
| Throat swelling and tightness | 11 (5.9) | 5 (5.4) | > 0.99 | 7 (8.0) | 5 (4.9) | 3 (8.6) | 0 (0) | 1 (3.6) | 0.25 | ||
| Hoarseness | 6 (3.2) | 0 (0) | 0.19 | 4 (4.6) | 2 (1.9) | 0 (0) | 0 (0) | 0 (0) | 0.06 | ||
| Odynophagia | 7 (3.8) | 0 (0) | 0.14 | 6 (6.9) | 1 (1.0) | 0 (0) | 0 (0) | 0 (0) | 0.02 | ||
| Wheezing | 1 (0.5) | 1 (1.1) | > 0.99 | 1 (1.1) | 0 (0) | 0 (0) | 0 (0) | 1 (3.6) | 0.43 | ||
| Chest discomfort | 1 (0.5) | 0 (0) | > 0.99 | 1 (1.1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0.31 | ||
| Urticaria | 2 (1.1) | 0 (0) | 0.81 | 2 (2.3) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0.15 | ||
| Skin rash | 5 (2.7) | 0 (0) | 0.27 | 5 (5.7) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0.02 | ||
| Antipyretic use | 72 (38.9) | 23 (25.0) | 0.03 | 33 (37.9) | 35 (34.0) | 11 (31.4) | 7 (29.2) | 9 (32.1) | 0.40 | ||
Data are presented as number (%).