Table 2.
Univariate and multivariable analyses assessing the association between predictor variables and overall survival mortality among 107 patients for UTUC.
| Characteristics | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95%CI | P-value | Hazard Ratio | 95%CI | P-value | |
| Age, years | ||||||
| ≥ 65 vs < 65 | 1.110 | 0.649-1.894 | 0.704 | 0.875 | 0.482-1.588 | 0.660 |
| Gender | ||||||
| Male vs Female | 0.699 | 0.404-1.207 | 0.199 | 0.754 | 0.428-1.328 | 0.329 |
| Multifocal upper tract disease | ||||||
| Multifocal vs Single | 1.136 | 0.571-2.260 | 0.716 | 0.963 | 0.467-1.985 | 0.919 |
| Histologic grade | ||||||
| High vs Low | 1.758 | 1.002-3.084 | 0.049 | 1.439 | 0.804-2.575 | 0.220 |
| pT stage | ||||||
| T2/T3/T4 vs Ta/T1 | 2.185 | 1.232-3.875 | 0.008 | 1.893 | 1.059-3.385 | 0.031 |
| LNM | ||||||
| Yes vs No | 2.631 | 1.536-4.506 | <0.001 | 2.152 | 1.245-3.721 | 0.006 |
| LVI | ||||||
| Present vs Absent | 1.824 | 1.066-3.121 | 0.028 | 0.844 | 0.427-1.668 | 0.625 |
| Histological differentiation | ||||||
| Pure urothelial vs Variant histology a | 1.017 | 0.497-2.081 | 0.963 | 0.870 | 0.406-1.867 | 0.721 |
| Adjuvant therapy | ||||||
| Yes vs No | 1.887 | 1.084-3.282 | 0.025 | 1.203 | 0.662-2.187 | 0.543 |
| Neoadjuvant chemotherapy | ||||||
| Yes vs No | 1.000 | 0.472-2.119 | 1.000 | 1.187 | 0.131-10.789 | 0.879 |
| FOXO3A expression | ||||||
| Low vs High | 2.382 | 1.312-4.327 | 0.004 | 2.145 | 1.167-3.941 | 0.014 |
LNM, lymph node metastasis; LVI, lymphovascular invasion; pT, pathological tumor stage.
a
Variant histology included micropapillary, plasmocytoid, sarcomatoid, and neuroendocrine types.