Table 3.
Univariate and multivariable analyses assessing the association between predictor variables and recurrence among 107 patients for UTUC.
| Characteristics | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95%CI | P-value | Hazard Ratio | 95%CI | P-value | |
| Age, years | ||||||
| ≥ 65 vs < 65 | 1.100 | 0.645-1.877 | 0.726 | 0.876 | 0.490-1.567 | 0.655 |
| Gender | ||||||
| Male vs Female | 0.671 | 0.386-1.167 | 0.158 | 0.713 | 0.403-1.263 | 0.247 |
| Multifocal upper tract disease | ||||||
| Multifocal vs Single | 1.189 | 0.598-2.367 | 0.621 | 0.971 | 0.470-2.005 | 0.913 |
| Histologic grade | ||||||
| High vs Low | 1.708 | 0.975-2.993 | 0.062 | 1.298 | 0.715-2.356 | 0.391 |
| pT stage | ||||||
| T2/T3/T4 vs Ta/T1 | 2.181 | 1.229-3.871 | 0.008 | 1.971 | 1.102-3.527 | 0.022 |
| LNM | ||||||
| Yes vs No | 2.708 | 1.580-4.643 | <0.001 | 2.257 | 1.306-3.900 | 0.004 |
| LVI | ||||||
| Present vs Absent | 1.834 | 1.069-3.144 | 0.028 | 0.844 | 0.426-1.670 | 0.626 |
| Histological differentiation | ||||||
| Pure urothelial vs Variant histologya | 1.055 | 0.515-2.165 | 0.883 | 0.860 | 0.397-1.865 | 0.703 |
| Adjuvant therapy | ||||||
| Yes vs No | 1.991 | 1.142-3.471 | 0.015 | 1.402 | 0.779-2.521 | 0.259 |
| Neoadjuvant chemotherapy | ||||||
| Yes vs No | 1.039 | 0.488-2.209 | 0.922 | 1.144 | 0.125-10.491 | 0.906 |
| FOXO3A expression | ||||||
| Low vs High | 2.385 | 1.314-4.329 | 0.004 | 2.227 | 1.209-4.101 | 0.010 |
LNM, lymph node metastasis; LVI, lymphovascular invasion; pT, pathological tumor stage.
aVariant histology included micropapillary, plasmocytoid, sarcomatoid, and neuroendocrine types.